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  • 产品名称：Junctional Adhesion Molecule 1 Positive Control peptide (STJ504330)

  • 产品型号：STJ504330-5
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Junctional Adhesion Molecule 1 Positive Control peptide (STJ504330)
详情介绍：
Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Junctional Adhesion Molecule 1 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: F11R
Gene ID: 50848
Uniprot ID: JAM1_HUMAN
Tissue Specificity Expressed in endothelium, epithelium and leukocytes (at protein level).
Post Translational Modifications N-glycosylated. (Microbial infection) Cleaved by H.pylori virulence factor PqqE. Cleavage leads to altered tight junction functions.
Function Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation. (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1. (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.
Peptide Name Junctional Adhesion Molecule A
Jam-A
Junctional Adhesion Molecule 1
Jam-1
Platelet F11 Receptor
Platelet Adhesion Molecule 1
Pam-1
Cd Antigen Cd321
Database Links Reactome: R-HSA-202733
Reactome: R-HSA-216083
Reactome: R-HSA-2173791
Reactome: R-HSA-420029
Cellular Localisation Cell Junction
Tight Junction
Cell Membrane
Single-Pass Type I Membrane Protein
Localized At Tight Junctions Of Both Epithelial And Endothelial Cells
Alternative Peptide Names Junctional Adhesion Molecule A protein
Jam-A protein
Junctional Adhesion Molecule 1 protein
Jam-1 protein
Platelet F11 Receptor protein
Platelet Adhesion Molecule 1 protein
Pam-1 protein
Cd Antigen Cd321 protein
F11R protein
JAM1 protein
JCAM protein
UNQ264 protein
PRO301 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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