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  • 产品名称：Anti-AKR1A1 antibody (1-325) (STJ115538)

  • 产品型号：STJ115538
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-AKR1A1 antibody (1-325) (STJ115538)
详情介绍：
Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-AKR1A1 (1-325) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:200
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: AKR1A1
Gene ID: 10327
Uniprot ID: AK1A1_HUMAN
Immunogen Region: 1-325
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human AKR1A1 (NP_006057.1).
Immunogen Sequence: MAASCVLLHTGQKMPLIGLG TWKSEPGQVKAAVKYALSVG YRHIDCAAIYGNEPEIGEAL KEDVGPGKAVPREELFVTSK LWNTKHHPEDVEPALRKTLA DLQLEYLDLYLMHWPYAFER GDNPFPKNADGTICYDSTHY KETWKALEALVAKGLVQALG LSNFNSRQIDDILSVASVRP AVLQVECHPYLAQNELIAHC QARGLEVTAYSPLGSSDRAW RDPDEPVLLEEPVVLALAE
Tissue Specificity Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.
Function Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde. Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Displays no reductase activity towards retinoids.
Protein Name Aldo-Keto Reductase Family 1 Member A1
Alcohol Dehydrogenase Nadp(+
Aldehyde Reductase
Glucuronate Reductase
Glucuronolactone Reductase
Database Links Reactome: R-HSA-156590
Reactome: R-HSA-5661270
Cellular Localisation Cytoplasm
Cytosol
Apical Cell Membrane
Alternative Antibody Names Anti-Aldo-Keto Reductase Family 1 Member A1 antibody
Anti-Alcohol Dehydrogenase Nadp(+ antibody
Anti-Aldehyde Reductase antibody
Anti-Glucuronate Reductase antibody
Anti-Glucuronolactone Reductase antibody
Anti-AKR1A1 antibody
Anti-ALDR1 antibody
Anti-ALR antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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