产品详情
简单介绍：
Anti-AKR1C2 antibody (21-70 aa) (STJ92670)
详情介绍：
| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Aldo-keto reductase family 1 member C2 (21-70 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:20000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AKR1C2 |
| Gene ID: | 1646 |
| Uniprot ID: | AK1C2_HUMAN |
| Immunogen Region: | 21-70 aa |
| Specificity: | DD2 Polyclonal Antibody detects endogenous levels of DD2 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human AKR1C2 at the amino acid range 21-70 |
| Function | Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH. Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens. Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Also specifically able to produce 17beta-hydroxy-5alpha-androstan-3-one/5alphaDHT. May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate. Displays affinity for bile acids. |
| Protein Name | Aldo-Keto Reductase Family 1 Member C2 3-Alpha-Hsd3 Chlordecone Reductase Homolog Hakrd Dihydrodiol Dehydrogenase 2 Dd-2 Dd2 Dihydrodiol Dehydrogenase/Bile Acid-Binding Protein Dd/Babp Type Iii 3-Alpha-Hydroxysteroid Dehydrogenase |
| Database Links | Reactome: R-HSA-193368 Reactome: R-HSA-193775 Reactome: R-HSA-193807 |
| Cellular Localisation | Cytoplasm Cytosol |
| Alternative Antibody Names | Anti-Aldo-Keto Reductase Family 1 Member C2 antibody Anti-3-Alpha-Hsd3 antibody Anti-Chlordecone Reductase Homolog Hakrd antibody Anti-Dihydrodiol Dehydrogenase 2 antibody Anti-Dd-2 antibody Anti-Dd2 antibody Anti-Dihydrodiol Dehydrogenase/Bile Acid-Binding Protein antibody Anti-Dd/Babp antibody Anti-Type Iii 3-Alpha-Hydroxysteroid Dehydrogenase antibody Anti-AKR1C2 antibody Anti-DDH2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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