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  • 产品名称：KIF14 Positive Control for STJ501537 peptide (STJ504335)

  • 产品型号：STJ504335-5
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
KIF14 Positive Control for STJ501537 peptide (STJ504335)
详情介绍：
Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: KIF14 Positive Control for STJ501537 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: KIF14
Gene ID: 9928
Uniprot ID: KIF14_HUMAN
Specificity: This is positive control is recommended for use in combination with KIF14 antibody STJ501537.
Function Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity. Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis. During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively. Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1. During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division. Also is required for chromosome congression and alignment during mitotic cell cycle process. Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules.
Peptide Name Kinesin-Like Protein Kif14
Database Links Reactome: R-HSA-5625900
Reactome: R-HSA-9696270
Reactome: R-HSA-9696273
Cellular Localisation Nucleus
Cytoplasm
Cytoskeleton
Spindle
Midbody
Nuclear Localization Observed During Interphase
Nuclear Localization Triggered By Entry Into Mitosis
Cytoplasmic In Interphase
Cytoplasmic In Metaphase Cells
From Prophase To Metaphase
Accumulates At The Developing Spindle Poles And Their Associated Microtubules
During Anaphase
Accumulates At The Spindle Midzone
Localization To The Central Spindle And Midbody During Anaphase Is Dependent Upon Prc1 And Cit Presence
In Cells Ready To Undergo Abscission
Concentrates At The Contractile Ring
Alternative Peptide Names Kinesin-Like Protein Kif14 protein
KIF14 protein
KIAA0042 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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