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  • 产品名称：MAPK9 Blocking Peptide for STJ501719 peptide (STJ505425)

  • 产品型号：STJ505425-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
MAPK9 Blocking Peptide for STJ501719 peptide (STJ505425)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: MAPK9 Blocking Peptide for STJ501719 is synthetically produced from the 370-420 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: MAPK9
Gene ID: 5601
Uniprot ID: MK09_HUMAN
Immunogen Region: 370-420
Specificity: This blocking peptide is recommended for use in combination with MAPK9 antibody, STJ501719
Immunogen: Synthetic peptide taken within amino acid region 370-420 on human Mitogen-activated protein kinase 9.
Post Translational Modifications Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Autophosphorylated in vitro.
Function Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the regulation of the circadian clock. Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteasomal degradation. MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.
Peptide Name Mitogen-Activated Protein Kinase 9
Map Kinase 9
Mapk 9
Jnk-55
Stress-Activated Protein Kinase 1a
Sapk1a
Stress-Activated Protein Kinase Jnk2
C-Jun N-Terminal Kinase 2
Database Links Reactome: R-HSA-2559580
Reactome: R-HSA-2871796
Reactome: R-HSA-450321
Reactome: R-HSA-450341
Cellular Localisation Cytoplasm
Nucleus
Colocalizes With Pou5f1 In The Nucleus
Alternative Peptide Names Mitogen-Activated Protein Kinase 9 protein
Map Kinase 9 protein
Mapk 9 protein
Jnk-55 protein
Stress-Activated Protein Kinase 1a protein
Sapk1a protein
Stress-Activated Protein Kinase Jnk2 protein
C-Jun N-Terminal Kinase 2 protein
MAPK9 protein
JNK2 protein
PRKM9 protein
SAPK1A protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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