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  • 产品名称：Human NEPH1 protein (Recombinant) (STJP000672)

  • 产品型号：STJP000672
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human NEPH1 protein (Recombinant) (STJP000672)
详情介绍：
Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human NEPH1-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose.
Dilution Range: Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
Storage Instruction: Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA
Immunoreactivity: The activity was tested by the ability of immobilized recombinant human NEPH1 to bind mouse MS-1 endothelial cells, after 90 min 75% of cells will adhere. NA
Gene Symbol: KIRREL1
Gene ID: 55243
Uniprot ID: KIRR1_HUMAN
Immunogen Region: GLN17-ALA499
Immunogen: Optimized DNA sequence encoding extracellular domain of NEPH1 (GLN17-ALA499 ) including a C-terminal His tag was expressed in HEK293 cells. NA
Tissue Specificity Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.
Post Translational Modifications Phosphorylation probably regulates the interaction with NSH2. Phosphorylated at Tyr-605 and Tyr-606 by FYN, leading to GRB2 binding. N-glycosylated.
Function Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm. It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.
Protein Name Kin Of Irre-Like Protein 1
Kin Of Irregular Chiasm-Like Protein 1
Nephrin-Like Protein 1
Database Links Reactome: R-HSA-373753
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Predominantly Located At Podocyte Slit Diaphragm
Alternative Protein Names Kin Of Irre-Like Protein 1 protein
Kin Of Irregular Chiasm-Like Protein 1 protein
Nephrin-Like Protein 1 protein
KIRREL1 protein
KIRREL protein
NEPH1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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