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  • 产品名称：MLKL Positive Control for STJ506094 peptide (STJ505829)

  • 产品型号：STJ505829-5
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
MLKL Positive Control for STJ506094 peptide (STJ505829)
详情介绍：
Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: MLKL Positive Control for STJ506094 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Mlkl
Gene ID: 74568
Uniprot ID: MLKL_MOUSE
Specificity: This is positive control is recommended for use in combination with MLKL antibody STJ506094.
Tissue Specificity Highly expressed in thymus, colon, intestine, liver, spleen and lung. Expressed at much lower level in skeletal muscle, heart and kidney. Not detected in brain.
Post Translational Modifications Phosphorylation by RIPK3 induces a conformational switch that is required for necroptosis. It also induces homotrimerization and localization to the plasma membrane.
Function Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol. Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function.
Peptide Name Mixed Lineage Kinase Domain-Like Protein
Database Links Reactome: R-MMU-3295583
Reactome: -MMU-5213460
Reactome: -MMU-5675482
Cellular Localisation Cytoplasm
Cell Membrane
Nucleus
Localizes To The Cytoplasm And Translocates To The Plasma Membrane On Necroptosis Induction
Localizes To The Nucleus In Response To Orthomyxoviruses Infection
Alternative Peptide Names Mixed Lineage Kinase Domain-Like Protein protein
Mlkl protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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