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  • 产品名称：Myosin 1C Blocking Peptide for STJ501852 peptide (STJ505679)

  • 产品型号：STJ505679-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Myosin 1C Blocking Peptide for STJ501852 peptide (STJ505679)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Myosin 1C Blocking Peptide for STJ501852 is synthetically produced from the 1-50 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Myo1c
Gene ID: 17913
Uniprot ID: MYO1C_MOUSE
Immunogen Region: 1-50
Specificity: This blocking peptide is recommended for use in combination with Myosin 1C antibody, STJ501852
Immunogen: Synthetic peptide taken within amino acid region 1-50 on mouse Unconventional Myosin-Ic/Myo 1C.
Tissue Specificity Isoform 3 is expressed in small intestine, pancreas, brain, kidney, skin, heart muscle, testis, striated muscle, spleen, liver and lung (at protein level). Expressed in brain, testis, adrenal glands, thymus, spleen, kidney, lung, heart, cochlea and vestibule. Expressed in sensory hair cells of the inner ear. Expressed in adipocytes.
Post Translational Modifications Isoform 2 contains a N-acetylmethionine at position 1.
Function Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which then are moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. Isoform 3: Involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation.
Peptide Name Unconventional Myosin-Ic
Myosin I Beta
Mmi-Beta
Mmib
Database Links Reactome: R-MMU-2029482
Reactome: -MMU-5250924
Cellular Localisation Cytoplasm
Nucleus
Cell Cortex
Cell Projection
Stereocilium Membrane
Cytoplasmic Vesicle
Ruffle Membrane
Colocalizes With Cabp1 And Cib1 At Cell Margin
Membrane Ruffles And Punctate Regions On The Cell Membrane
Colocalizes In Adipocytes With Glut4 At Actin-Based Membranes
Colocalizes With Glut4 At Insulin-Induced Ruffles At The Cell Membrane
Localizes Transiently At Cell Membrane To Region Known To Be Enriched In Pip2
Activation Of Phospholipase C Results In Its Redistribution To The Cytoplasm
Colocalizes With Rna Polymerase Ii
Translocates To Nuclear Speckles Upon Exposure To Inhibitors Of Rna Polymerase Ii Transcription
Isoform 3: Nucleus
Nucleolus
Nucleoplasm
Colocalizes With Rna Polymerase Ii In The Nucleus
Colocalizes With Rna Polymerase I In Nucleoli
In The Nucleolus
Is Localized Predominantly In Dense Fibrillar Component (Dfc) And In Granular Component (Gc)
Accumulates Strongly In Dfc And Gc During Activation Of Transcription
Colocalizes With Transcription Sites
Colocalizes In The Granular Cortex At The Periphery Of The Nucleolus With Rps6
Colocalizes In Nucleoplasm With Rps6 And Actin That Are In Contact With Rnp Particles
Colocalizes With Rps6 At The Nuclear Pore Level
Alternative Peptide Names Unconventional Myosin-Ic protein
Myosin I Beta protein
Mmi-Beta protein
Mmib protein
Myo1c protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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