产品详情
查看大图

  • 产品名称：Anti-ALYREF antibody (1-100) (STJ27806)

  • 产品型号：STJ27806
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Anti-ALYREF antibody (1-100) (STJ27806)
详情介绍：
Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ALYREF (1-100) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:200
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ALYREF
Gene ID: 10189
Uniprot ID: THOC4_HUMAN
Immunogen Region: 1-100
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human THOC4/THOC4/ALYREF (NP_005773.3).
Immunogen Sequence: MPDSAPAMADKMDMSLDDII KLNRSQRGGRGGGRGRGRAG SQGGRGGGAQAAARVNRGGG PIRNRPAIARGAAGGGGRNR PAPYSRPKQLPDKWQHDLFD
Tissue Specificity Expressed in a wide variety of cancer types.
Post Translational Modifications Arg-204 is dimethylated, probably to asymmetric dimethylarginine. Arginine methylation reduces RNA binding. Citrullinated by PADI4.
Function Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm. TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA. Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA.both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in the nuclear export of intronless mRNA.proposed to be recruited to intronless mRNA by ATP-bound DDX39B. Involved in transcription elongation and genome stability. Involved in mRNA export of C5-methylcytosine (m5C)-containing mRNAs: specifically recognizes and binds m5C mRNAs and mediates their nucleo-cytoplasmic shuttling. Acts as chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation.
Protein Name Tho Complex Subunit 4
Tho4
Ally Of Aml-1 And Lef-1
Aly/Ref Export Factor
Transcriptional Coactivator Aly/Ref
Bzip-Enhancing Factor Bef
Database Links Reactome: R-HSA-159227
Reactome: R-HSA-159230
Reactome: R-HSA-159231
Reactome: R-HSA-159236
Reactome: R-HSA-72163
Reactome: R-HSA-72187
Reactome: R-HSA-73856
Cellular Localisation Nucleus
Nucleus Speckle
Cytoplasm
Colocalizes With The Core Ejc
Alyref/Thoc4
Nxf1 And Ddx39b In The Nucleus And Nuclear Speckles
Travels To The Cytoplasm As Part Of The Exon Junction Complex (Ejc) Bound To Mrna
Localizes To Regions Surrounding Nuclear Speckles Known As Perispeckles In Which Trex Complex Assembly Seems To Occur
Alternative Antibody Names Anti-Tho Complex Subunit 4 antibody
Anti-Tho4 antibody
Anti-Ally Of Aml-1 And Lef-1 antibody
Anti-Aly/Ref Export Factor antibody
Anti-Transcriptional Coactivator Aly/Ref antibody
Anti-Bzip-Enhancing Factor Bef antibody
Anti-ALYREF antibody
Anti-ALY antibody
Anti-BEF antibody
Anti-THOC4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号