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  • 产品名称：Anti-AMFR antibody (384-643) (STJ22602)

  • 产品型号：STJ22602
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-AMFR antibody (384-643) (STJ22602)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-AMFR (384-643) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: AMFR
Gene ID: 267
Uniprot ID: AMFR_HUMAN
Immunogen Region: 384-643
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 384-643 of human AMFR (NP_001135.3).
Immunogen Sequence: IADNNRVREEHQGENLDENL VPVAAAEGRPRLNQHNHFFH FDGSRIASWLPSFSVEVMHT TNILGITQASNSQLNAMAHQ IQEMFPQVPYHLVLQDLQLT RSVEITTDNILEGRIQVPFP TQRSDSIRPALNSPVERPSS DQEEGETSAQTERVPLDLSP RLEETLDFGEVEVEPSEVED FEARGSRFSKSADERQRMLV QRKDELLQQARKRFLNKSSE DDAASESFLPSEGASSDPV
Post Translational Modifications Palmitoylation of the RING-type zing finger by ZDHHC6 promotes localization to the peripheral endoplasmic reticulum.
Function E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane. In addition, interaction of AMFR with AUP1 facilitates interaction of AMFR with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase RNF139, leading to sterol-induced HMGCR ubiquitination. The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction. In addition to ubiquitination on lysine residues, catalyzes ubiquitination on cysteine residues: together with INSIG1, mediates polyubiquitination of SOAT2/ACAT2 at 'Cys-277', leading to its degradation when the lipid levels are low. Catalyzes ubiquitination and subsequent degradation of INSIG1 when cells are depleted of sterols. Mediates polyubiquitination of INSIG2 at 'Cys-215' in some tissues, leading to its degradation. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor. In association with LMBR1L and UBAC2, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6. Regulates NF-kappa-B and MAPK signaling pathways by mediating 'Lys-27'-linked polyubiquitination of TAB3 and promoting subsequent TAK1/MAP3K7 activation.
Protein Name E3 Ubiquitin-Protein Ligase Amfr
Autocrine Motility Factor Receptor
Amf Receptor
Ring Finger Protein 45
Gp78
Database Links Reactome: R-HSA-532668
Reactome: R-HSA-901032
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Palmitoylation Promotes Localization To The Peripheral Endoplasmic Reticulum
Alternative Antibody Names Anti-E3 Ubiquitin-Protein Ligase Amfr antibody
Anti-Autocrine Motility Factor Receptor antibody
Anti-Amf Receptor antibody
Anti-Ring Finger Protein 45 antibody
Anti-Gp78 antibody
Anti-AMFR antibody
Anti-RNF45 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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