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  • 产品名称：Human ATP2C1 (Calcium-Transporting ATPase Type 2C Member 1) Sandwich ELISA Kit Ready-To-Use (STJE0013765)

  • 产品型号：STJE0013765
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human ATP2C1 (Calcium-Transporting ATPase Type 2C Member 1) Sandwich ELISA Kit Ready-To-Use (STJE0013765)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.077ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This ATP2C1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: ATP2C1
Gene ID: 27032
Uniprot ID: AT2C1_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity Found in most tissues except colon, thymus, spleen and leukocytes. Expressed in keratinocytes (at protein level).
Post Translational Modifications
Function ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway. Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state. Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology. Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity. Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity. May also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity.
Protein Name Calcium-Transporting Atpase Type 2c Member 1
Atpase 2c1
Atp-Dependent Ca(2+ Pump Pmr1
Ca(2+/Mn(2+-Atpase 2c1
Secretory Pathway Ca(2+-Transporting Atpase Type 1
Spca1
Database Links Reactome: R-HSA-936837
Cellular Localisation Golgi Apparatus
Trans-Golgi Network Membrane
Multi-Pass Membrane Protein
Golgi Stack Membrane
During Neuron Differentiation
Shifts From Juxtanuclear Golgi Position To Multiple Golgi Structures Distributed Over The Neural Soma With A Predominance In The Apical Dendritic Trunk
Alternative ELISA Names Calcium-Transporting Atpase Type 2c Member 1 ELISA kit
Atpase 2c1 ELISA kit
Atp-Dependent Ca(2+ Pump Pmr1 ELISA kit
Ca(2+/Mn(2+-Atpase 2c1 ELISA kit
Secretory Pathway Ca(2+-Transporting Atpase Type 1 ELISA kit
Spca1 ELISA kit
ATP2C1 ELISA kit
KIAA1347 ELISA kit
PMR1L ELISA kit
HUSSY-28 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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