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  • 产品名称：Human ATP4b (ATPase, H+/K+ Exchanging Beta Polypeptide) Sandwich ELISA Kit (STJE0007393)

  • 产品型号：STJE0007393
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human ATP4b (ATPase, H+/K+ Exchanging Beta Polypeptide) Sandwich ELISA Kit (STJE0007393)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.059ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This ATP4b Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: ATP4B
Gene ID: 496
Uniprot ID: ATP4B_HUMAN
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications N-glycosylation is necessary for assembly and functional expression of the pump at the plasma membrane.
Function The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump. Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle.
Protein Name Potassium-Transporting Atpase Subunit Beta
Gastric H(+/K(+ Atpase Subunit Beta
Proton Pump Beta Chain
Database Links Reactome: R-HSA-936837
Cellular Localisation Apical Cell Membrane
Single-Pass Type Ii Membrane Protein
Cell Membrane
Localized In The Apical Canalicular Membrane Of Parietal Cells
Alternative ELISA Names Potassium-Transporting Atpase Subunit Beta ELISA kit
Gastric H(+/K(+ Atpase Subunit Beta ELISA kit
Proton Pump Beta Chain ELISA kit
ATP4B ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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