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  • 产品名称：NKG2D Positive Control for STJ501925 peptide (STJ504481)

  • 产品型号：STJ504481-5
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
NKG2D Positive Control for STJ501925 peptide (STJ504481)
详情介绍：
Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: NKG2D Positive Control for STJ501925 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Klrk1
Gene ID: 24934
Uniprot ID: NKG2D_RAT
Specificity: This is positive control is recommended for use in combination with NKG2D antibody STJ501925.
Tissue Specificity Expressed by natural killer cells and by resting thoracic duct CD4+ and CD8+ T-cells, but not by thymocytes or other hemopoietic cells. Expressed by DC cells.
Function Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins.
Peptide Name Nkg2-D Type Ii Integral Membrane Protein
Killer Cell Lectin-Like Receptor Subfamily K Member 1
Nk Cell Receptor D
Nk Lectin-Like Receptor
Nkllr
Nkg2-D-Activating Nk Receptor
Nkr-P2
Cd Antigen Cd314
Database Links Reactome: R-RNO-198933
Reactome: -RNO-2424491
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Colocalized With Hcst On The Cell Surface
Alternative Peptide Names Nkg2-D Type Ii Integral Membrane Protein protein
Killer Cell Lectin-Like Receptor Subfamily K Member 1 protein
Nk Cell Receptor D protein
Nk Lectin-Like Receptor protein
Nkllr protein
Nkg2-D-Activating Nk Receptor protein
Nkr-P2 protein
Cd Antigen Cd314 protein
Klrk1 protein
Nkg2d protein
Nkrp2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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