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  • 产品名称：Npas4 Blocking Peptide peptide (STJ504423)

  • 产品型号：STJ504423-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Npas4 Blocking Peptide peptide (STJ504423)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Npas4 Blocking Peptide is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: NPAS4
Gene ID: 266743
Uniprot ID: NPAS4_HUMAN
Immunogen: Synthetic peptide corresponding to unique amino acid sequence on human Npas4 protein.
Tissue Specificity Brain.
Post Translational Modifications Ubiquitinated, leading to degradation by the proteosome.
Function Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hippocampus. Plays a key role in the structural and functional plasticity of neurons. Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience. In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons. In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits. The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior. Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2. Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1. Can activate the CME (CNS midline enhancer) element.
Peptide Name Neuronal Pas Domain-Containing Protein 4
Neuronal Pas4
Class E Basic Helix-Loop-Helix Protein 79
Bhlhe79
Hlh-Pas Transcription Factor Nxf
Pas Domain-Containing Protein 10
Database Links Reactome: R-HSA-9768778
Reactome: R-HSA-9768919
Cellular Localisation Nucleus
Alternative Peptide Names Neuronal Pas Domain-Containing Protein 4 protein
Neuronal Pas4 protein
Class E Basic Helix-Loop-Helix Protein 79 protein
Bhlhe79 protein
Hlh-Pas Transcription Factor Nxf protein
Pas Domain-Containing Protein 10 protein
NPAS4 protein
BHLHE79 protein
NXF protein
PASD10 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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