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  • 产品名称：Human ATP7b (ATPase, Cu++ Transporting Beta Polypeptide) Sandwich ELISA Kit Ready-To-Use (STJE0013775)

  • 产品型号：STJE0013775
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human ATP7b (ATPase, Cu++ Transporting Beta Polypeptide) Sandwich ELISA Kit Ready-To-Use (STJE0013775)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.056ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This ATP7b Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: ATP7B
Gene ID: 540
Uniprot ID: ATP7B_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver. The cleaved form WND/140 kDa is found in liver cell lines and other tissues.
Post Translational Modifications Isoform 1 may be proteolytically cleaved at the N-terminus to produce the WND/140 kDa form.
Function Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload.
Protein Name Copper-Transporting Atpase 2
Copper Pump 2
Wilson Disease-Associated Protein Cleaved Into - Wnd/140 Kda
Database Links Reactome: R-HSA-936837
Cellular Localisation Golgi Apparatus
Trans-Golgi Network Membrane
Multi-Pass Membrane Protein
Late Endosome
Predominantly Found In The Trans-Golgi Network (Tgn)
Localized In The Trans-Golgi Network Under Low Copper Conditions
Redistributes To Cytoplasmic Vesicles When Cells Are Exposed To Elevated Copper Levels
And Then Recycles Back To The Trans-Golgi Network When Copper Is Removed
Isoform 1: Golgi Apparatus Membrane
Isoform 2: Cytoplasm
Wnd/140 Kda: Mitochondrion
Alternative ELISA Names Copper-Transporting Atpase 2 ELISA kit
Copper Pump 2 ELISA kit
Wilson Disease-Associated Protein Cleaved Into - Wnd/140 Kda ELISA kit
ATP7B ELISA kit
PWD ELISA kit
WC1 ELISA kit
WND ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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