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  • 产品名称：Human BAI1 (Brain Specific Angiogenesis Inhibitor 1) Sandwich ELISA Kit (STJE0007427)

  • 产品型号：STJE0007427
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human BAI1 (Brain Specific Angiogenesis Inhibitor 1) Sandwich ELISA Kit (STJE0007427)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.065ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This BAI1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: ADGRB1
Gene ID: 575
Uniprot ID: AGRB1_HUMAN
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Expressed in brain (at protein level). Expressed on mononuclear phagocytes and monocyte-derived macrophages in the gastric mucosa (at protein level). Expressed in normal pancreatic tissue but not in pancreatic tumor tissue. Reduced or no expression is observed in some glioblastomas.
Post Translational Modifications Proteolytically cleaved to produce vasculostatin-40 and vasculostatin-120. Vasculostatin-40 is the major form and is produced through proteolytic cleavage by MMP14 between residues 321 and 329 with cleavage likely to be between Ser-326 and Leu-327. Ubiquitinated.
Function Phosphatidylserine receptor which enhances the engulfment of apoptotic cells. Also mediates the binding and engulfment of Gram-negative bacteria. Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity. In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells. Promotes myoblast fusion. Activates the Rho pathway in a G-protein-dependent manner. Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity. Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1. Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma. Vasculostatin-120: Inhibits angiogenesis in a CD36-dependent manner. Vasculostatin-40: Inhibits angiogenesis.
Protein Name Adhesion G Protein-Coupled Receptor B1
Brain-Specific Angiogenesis Inhibitor 1 Cleaved Into - Vasculostatin-40
Vstat40 - Vasculostatin-120
Vstat120
Database Links
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Phagocytic Cup
Cell Junction
Focal Adhesion
Dendritic Spine
Postsynaptic Density
Vasculostatin-120: Secreted
Vasculostatin-40: Secreted
Alternative ELISA Names Adhesion G Protein-Coupled Receptor B1 ELISA kit
Brain-Specific Angiogenesis Inhibitor 1 Cleaved Into - Vasculostatin-40 ELISA kit
Vstat40 - Vasculostatin-120 ELISA kit
Vstat120 ELISA kit
ADGRB1 ELISA kit
BAI1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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