产品详情
简单介绍:
Human Serpin A3/Alpha-1-antichymotrypsin protein (Recombinant) (C-His) (STJP000967)
详情介绍:
Host: | HEK293 cells |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Recombinant-Human Serpin A3/Alpha-1-antichymotrypsin-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
Formulation: | Lyophilized from a 0.22 Mu m filtered solution of 20mM HEPES, 150mM NaCl, pH 8.0. Contact us for customized product form or formulation. |
Immunoreactivity: | Measured by its ability to inhibit chymotrypsin cleavage of a fluorogenic peptide substrate MCA-RPKPVE-Nval-WRK (Dnp)-NH2. The IC50 value is |
Gene Symbol: | SERPINA3 |
Gene ID: | 12 |
Uniprot ID: | AACT_HUMAN |
Immunogen: | Recombinant Human Serpin A3/Alpha-1-antichymotrypsin Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Asn26-Ala423) of human Serpin A3/AACT (Accession #NP_001076.2) fused with a 6×His tag at the C-termin |
Tissue Specificity | Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains. |
Post Translational Modifications | N- and O-glycosylated. |
Function | Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. |
Protein Name | Alpha-1-Antichymotrypsin Act Cell Growth-Inhibiting Gene 24/25 Protein Serpin A3 Cleaved Into - Alpha-1-Antichymotrypsin His-Pro-Less |
Database Links | Reactome: R-HSA-114608 Reactome: R-HSA-6798695 |
Cellular Localisation | Secreted |
Alternative Protein Names | Alpha-1-Antichymotrypsin protein Act protein Cell Growth-Inhibiting Gene 24/25 Protein protein Serpin A3 Cleaved Into - Alpha-1-Antichymotrypsin His-Pro-Less protein SERPINA3 protein AACT protein GIG24 protein GIG25 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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