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  • 产品名称：OTOP1 Blocking Peptide for STJ505981 peptide (STJ505752)

  • 产品型号：STJ505752-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
OTOP1 Blocking Peptide for STJ505981 peptide (STJ505752)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: OTOP1 Blocking Peptide for STJ505981 is synthetically produced from the 370-420 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: OTOP1
Gene ID: 133060
Uniprot ID: OTOP1_HUMAN
Immunogen Region: 370-420
Specificity: This blocking peptide is recommended for use in combination with OTOP1 antibody, STJ505981
Immunogen: Synthetic peptide taken within aino acid region 370-420on human Otopetrin-1.
Function Proton-selective channel that specifically transports protons into cells. Proton channel activity is only weakly-sensitive to voltage. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration. Probably acts by maintaining the pH appropriate for formation of otoconia. Regulates purinergic control of intracellular calcium in vestibular supporting cells. May be involved in sour taste perception in sour taste cells by mediating entry of protons within the cytosol. Also involved in energy metabolism, by reducing adipose tissue inflammation and protecting from obesity-induced metabolic dysfunction.
Peptide Name Proton Channel Otop1
Otopetrin-1
Hotop1
Database Links Reactome: R-HSA-9729555
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Detected In The Gelatinous Membrane Overlying The Inner Ear Macular Epithelium
Alternative Peptide Names Proton Channel Otop1 protein
Otopetrin-1 protein
Hotop1 protein
OTOP1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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