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  • 产品名称：Anti-ANK2 antibody (STJ198357)

  • 产品型号：STJ198357
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ANK2 antibody (STJ198357)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Ankyrin-2 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ANK2
Gene ID: 287
Uniprot ID: ANK2_HUMAN
Specificity: This antibody detects endogenous levels of Ankyrin B at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from the human Ankyrin B
Post Translational Modifications Phosphorylated at multiple sites by different protein kinases and each phosphorylation event regulates the protein's structure and function.
Function Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate. In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration.
Protein Name Ankyrin-2
Ank-2
Ankyrin-B
Brain Ankyrin
Non-Erythroid Ankyrin
Database Links Reactome: R-HSA-445095
Reactome: R-HSA-6807878
Cellular Localisation Cytoplasm
Cytoskeleton
Membrane
Myofibril
Sarcomere
M Line
Apical Cell Membrane
Cell Membrane
Postsynaptic Cell Membrane
Early Endosome
Recycling Endosome
Lysosome
Mitochondrion
Z Line
Sarcolemma
T-Tubule
Expressed At The Apical Membrane Of Airway Lung Epithelial Cells
Localized To The Plasma Membrane Of The Inner Segments Of Photoreceptors In Retina
Colocalizes With Sptbn1 In A Distinct Intracellular Compartment Of Neonatal Cardiomyocytes
In Skeletal Muscle
Localizes To Neuromuscular Junctions
Localizes With Puncta At Mitochondria Ends
Colocalizes And Cotransports On Motile Vesicles With Rabgap1l
Alternative Antibody Names Anti-Ankyrin-2 antibody
Anti-Ank-2 antibody
Anti-Ankyrin-B antibody
Anti-Brain Ankyrin antibody
Anti-Non-Erythroid Ankyrin antibody
Anti-ANK2 antibody
Anti-ANKB antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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