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  • 产品名称：Anti-ANKH antibody (210-320) (STJ111923)

  • 产品型号：STJ111923
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ANKH antibody (210-320) (STJ111923)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ANKH (210-320) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ANKH
Gene ID: 56172
Uniprot ID: ANKH_HUMAN
Immunogen Region: 210-320
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 210-320 of human ANKH (NP_473368.1).
Immunogen Sequence: LGYYKNIHDIIPDRSGPELG GDATIRKMLSFWWPLALILA TQRISRPIVNLFVSRDLGGS SAATEAVAILTATYPVGHMP YGWLTEIRAVYPAFDKNNPS NKLVSTSNTVT
Tissue Specificity Found in osteoblasts from mandibular bone and from iliac bone.not detected in osteoclastic cells.
Function Transports adenosine triphosphate (ATP) and possibly other nucleoside triphosphates (NTPs) from cytosol to the extracellular space. Mainly regulates their levels locally in peripheral tissues while playing a minor systemic role. Prevents abnormal ectopic mineralization of the joints by regulating the extracellular levels of the calcification inhibitor inorganic pyrophosphate (PPi), which originates from the conversion of extracellular NTPs to NMPs and PPis by ENPP1. Regulates the release of the TCA cycle intermediates to the extracellular space, in particular citrate, succinate and malate. Extracellular citrate mostly present in bone tissue is required for osteogenic differentiation of mesenchymal stem cells, stabilization of hydroxyapatite structure and overall bone strength. The transport mechanism remains to be elucidated (Probable).
Protein Name Mineralization Regulator Ankh
Atp Carrier Protein Ankh
Progressive Ankylosis Protein Homolog
Ank
Database Links Reactome: R-HSA-5223345
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Mineralization Regulator Ankh antibody
Anti-Atp Carrier Protein Ankh antibody
Anti-Progressive Ankylosis Protein Homolog antibody
Anti-Ank antibody
Anti-ANKH antibody
Anti-KIAA1581 antibody
Anti-UNQ241 antibody
Anti-PRO274 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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