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  • 产品名称：Anti-ANXA2 antibody (C-Term) [M298] (STJA0005258)

  • 产品型号：STJA0005258-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ANXA2 antibody (C-Term) [M298] (STJA0005258)
详情介绍：
Host: Mouse
Applications: WB/ICC/IHC/IP
Reactivity: Chicken/Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Annexin A2 (C-Term) is suitable for use in Western Blot, Immunocytochemistry, Immunohistochemistry and Immunoprecipitation research applications.
Clonality: Monoclonal
Clone ID: M298
Conjugation: Unconjugated
Isotype: IgG1
Formulation: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Purification: Protein A Purified
Dilution Range: WB 1:1000
IHC 1:50
ICC 1:50
IP 1:50
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ANXA2
Gene ID: 302
Uniprot ID: ANXA2_HUMAN
Immunogen Region: C-Term
Specificity: This antibody detects a 36 kDa* protein corresponding to the molecular mass of Annexin A2 on SDS-PAGE immunoblots of rat PC12 cells. The antibody has been shown to label Annexin A2 in immunocytochemical analysis of PC12 cells and immunohistochemical
Immunogen: Clone M009 was generated from a proprietary antigen related to human Annexin A2 in MDA-MB-231 breast cancer cell line.
Post Translational Modifications Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface. ISGylated.
Function Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen.
Protein Name Annexin A2
Annexin Ii
Annexin-2
Calpactin I Heavy Chain
Calpactin-1 Heavy Chain
Chromobindin-8
Lipocortin Ii
Placental Anticoagulant Protein Iv
Pap-Iv
Protein I
P36
Database Links Reactome: R-HSA-445355
Reactome: R-HSA-6798695
Reactome: R-HSA-75205
Reactome: R-HSA-8950505
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Basement Membrane
Melanosome
In The Lamina Beneath The Plasma Membrane
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Translocated From The Cytoplasm To The Cell Surface Through A Golgi-Independent Mechanism
Alternative Antibody Names Anti-Annexin A2 antibody
Anti-Annexin Ii antibody
Anti-Annexin-2 antibody
Anti-Calpactin I Heavy Chain antibody
Anti-Calpactin-1 Heavy Chain antibody
Anti-Chromobindin-8 antibody
Anti-Lipocortin Ii antibody
Anti-Placental Anticoagulant Protein Iv antibody
Anti-Pap-Iv antibody
Anti-Protein I antibody
Anti-P36 antibody
Anti-ANXA2 antibody
Anti-ANX2 antibody
Anti-ANX2L4 antibody
Anti-CAL1H antibody
Anti-LPC2D antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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