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  • 产品名称：Human TGF-beta RII/TGFBR2 protein (Recombinant) (C-mFc-Avi) {Biotin} (STJP001592)

  • 产品型号：STJP001592
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human TGF-beta RII/TGFBR2 protein (Recombinant) (C-mFc-Avi) {Biotin} (STJP001592)
详情介绍：
Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human TGF-beta RII/TGFBR2-C-mFc-Avi protein was developed from hek293 and has a target region of C-mFc-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: TGFBR2
Gene ID: 7048
Uniprot ID: TGFR2_HUMAN
Immunogen Region: Ile24-Asp159
Immunogen: DNA sequence encoding Human TGF-beta RII/TGFBR2 including a C-mFc-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Function Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and thus regulates a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. Isoform 1: Has transforming growth factor beta-activated receptor activity. Isoform 2: Has transforming growth factor beta-activated receptor activity. Isoform 3: Binds TGFB1, TGFB2 and TGFB3 in the picomolar affinity range without the participation of additional receptors. Blocks activation of SMAD2 and SMAD3 by TGFB1.
Protein Name Tgf-Beta Receptor Type-2
Tgfr-2
Tgf-Beta Type Ii Receptor
Transforming Growth Factor-Beta Receptor Type Ii
Tgf-Beta Receptor Type Ii
Tbetar-Ii
Database Links Reactome: R-HSA-2173788
Reactome: R-HSA-2173789
Reactome: R-HSA-2173791
Reactome: R-HSA-3304356
Reactome: R-HSA-3642279
Reactome: R-HSA-3645790
Reactome: R-HSA-3656532
Reactome: R-HSA-3656535
Reactome: R-HSA-5689603
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Membrane Raft
Isoform 3: Secreted
Alternative Protein Names Tgf-Beta Receptor Type-2 protein
Tgfr-2 protein
Tgf-Beta Type Ii Receptor protein
Transforming Growth Factor-Beta Receptor Type Ii protein
Tgf-Beta Receptor Type Ii protein
Tbetar-Ii protein
TGFBR2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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