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  • 产品名称：Anti-AOX1 antibody (340-590) (STJ22625)

  • 产品型号：STJ22625
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-AOX1 antibody (340-590) (STJ22625)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-AOX1 (340-590) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: AOX1
Gene ID: 316
Uniprot ID: AOXA_HUMAN
Immunogen Region: 340-590
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 340-590 of human AOX1 (NP_001150.3).
Immunogen Sequence: HLGTLAGSQIRNMASLGGHI ISRHPDSDLNPILAVGNCTL NLLSKEGKRQIPLNEQFLSK CPNADLKPQEILVSVNIPYS RKWEFVSAFRQAQRQENALA IVNSGMRVFFGEGDGIIREL CISYGGVGPATICAKNSCQK LIGRHWNEQMLDIACRLILN EVSLLGSAPGGKVEFKRTLI ISFLFKFYLEVSQILKKMDP VHYPSLADKYESALEDLHSK HHCSTLKYQNIGPKQHPED
Tissue Specificity Abundant in liver, expressed in adipose tissue and at lower levels in lung, skeletal muscle, pancreas. In contrast to mice, no significant gender difference in AOX1 expression level (at protein level).
Function Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. May also catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis.
Protein Name Aldehyde Oxidase
Aldehyde Oxidase 1
Azaheterocycle Hydroxylase
Database Links Reactome: R-HSA-964975
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Aldehyde Oxidase antibody
Anti-Aldehyde Oxidase 1 antibody
Anti-Azaheterocycle Hydroxylase antibody
Anti-AOX1 antibody
Anti-AO antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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