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  • 产品名称：Human TNFR2 (CD120b) protein (Recombinant) (STJP000475)

  • 产品型号：STJP000475
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human TNFR2 (CD120b) protein (Recombinant) (STJP000475)
详情介绍：
Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human TNFR2 (CD120b)-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: 0.2 Mu m filtered PBS solution, pH7.2.
Storage Instruction: Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Immunoreactivity: Recombinant Human TNF receptor 2 (CD120b) activity was determined by the ability to inhibit the TNF Alpha mediated cytotoxicity in the L929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is
Gene Symbol: TNFRSF1B
Gene ID: 7133
Uniprot ID: TNR1B_HUMAN
Immunogen Region: ECD
Immunogen: Optimized DNA sequence encoding extracellular domain of Human TNF receptor type 2 (TNFR2) including a C-terminal 6His tag was expressed in HEK293 cells. NA
Post Translational Modifications Phosphorylated.mainly on serine residues and with a very low level on threonine residues. A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
Function Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 1b
Tumor Necrosis Factor Receptor 2
Tnf-R2
Tumor Necrosis Factor Receptor Type Ii
Tnf-Rii
Tnfr-Ii
P75
P80 Tnf-Alpha Receptor
Cd Antigen Cd120b
Etanercept Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1b - Membrane Form - Tumor Necrosis Factor-Binding Protein 2
Tbp-2
Tbpii
Database Links Reactome: R-HSA-5668541
Reactome: R-HSA-5669034
Reactome: R-HSA-6783783
Reactome: R-HSA-6785807
Reactome: R-HSA-6798695
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Secreted
Tumor Necrosis Factor-Binding Protein 2: Secreted
Alternative Protein Names Tumor Necrosis Factor Receptor Superfamily Member 1b protein
Tumor Necrosis Factor Receptor 2 protein
Tnf-R2 protein
Tumor Necrosis Factor Receptor Type Ii protein
Tnf-Rii protein
Tnfr-Ii protein
P75 protein
P80 Tnf-Alpha Receptor protein
Cd Antigen Cd120b protein
Etanercept Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1b - Membrane Form - Tumor Necrosis Factor-Binding Protein 2 protein
Tbp-2 protein
Tbpii protein
TNFRSF1B protein
TNFBR protein
TNFR2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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