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  • 产品名称：PDE3A Positive Control for STJ502605 peptide (STJ504613)

  • 产品型号：STJ504613-5
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
PDE3A Positive Control for STJ502605 peptide (STJ504613)
详情介绍：
Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: PDE3A Positive Control for STJ502605 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PDE3A
Gene ID: 5139
Uniprot ID: PDE3A_HUMAN
Specificity: This is positive control is recommended for use in combination with PDE3A antibody STJ502605.
Function Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has also activity toward cUMP. Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling.
Peptide Name Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3a
Cyclic Gmp-Inhibited Phosphodiesterase A
Cgi-Pde A
Cgmp-Inhibited Camp Phosphodiesterase
Cgi-Pde
Database Links Reactome: R-HSA-418555
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Cytoplasm
Cytosol
Alternative Peptide Names Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3a protein
Cyclic Gmp-Inhibited Phosphodiesterase A protein
Cgi-Pde A protein
Cgmp-Inhibited Camp Phosphodiesterase protein
Cgi-Pde protein
PDE3A protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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