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  • 产品名称：Anti-APC antibody (1-100) [S6MR] (STJ11101456)

  • 产品型号：STJ11101456
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-APC antibody (1-100) [S6MR] (STJ11101456)
详情介绍：
Host: Rabbit
Applications: WB/IP
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-APC (1-100) is suitable for use in Western Blot and Immunoprecipitation research applications.
Clonality: Monoclonal
Clone ID: S6MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IP 1:100-1:500
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: APC
Gene ID: 324
Uniprot ID: APC_HUMAN
Immunogen Region: 1-100
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human APC (NP_000029.2).
Immunogen Sequence: MAAASYDQLLKQVEALKMEN SNLRQELEDNSNHLTKLETE ASNMKEVLKQLQGSIEDEAM ASSGQIDLLERLKELNLDSS NFPGVKLRSKMSLRSYGSRE
Tissue Specificity Expressed in a variety of tissues: brain, small intestine, colon, thymus, skeletal muscle, heart, prostate, lung, spleen, ovary, testis kidney, placenta, blood and liver. Isoform 1A: Very strongly expressed in brain but has relatively low expression levels in other tissues. Isoform 1B: Predominant form in all tissues except for brain, including gastric mucosa and blood.
Post Translational Modifications Phosphorylated.phosphorylation enhances the F-actin bundling activity. Phosphorylated by GSK3B. Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is facilitated by Axin. Deubiquitinated by ZRANB1/TRABID.
Function Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton. Plays a role in mediating the organization of F-actin into ordered bundles. Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Protein Name Adenomatous Polyposis Coli Protein
Protein Apc
Deleted In Polyposis 2.5
Database Links Reactome: R-HSA-111465
Reactome: R-HSA-195253
Reactome: R-HSA-196299
Reactome: R-HSA-3769402
Reactome: R-HSA-4641262
Reactome: R-HSA-5339716
Reactome: R-HSA-5358747
Reactome: R-HSA-5358749
Reactome: R-HSA-5358751
Reactome: R-HSA-5358752
Reactome: R-HSA-5467333
Reactome: R-HSA-5467337
Reactome: R-HSA-5467340
Reactome: R-HSA-5467348
Reactome: R-HSA-5689896
Cellular Localisation Cell Junction
Adherens Junction
Cytoplasm
Cytoskeleton
Cell Projection
Lamellipodium
Ruffle Membrane
Cell Membrane
Associated With The Microtubule Network At The Growing Distal Tip Of Microtubules
Mapre1 May Be Required For Targeting To The Growing Microtubule Plus Ends
Accumulates In The Lamellipodium And Ruffle Membrane In Response To Hepatocyte Growth Factor (Hgf) Treatment
The Memo1-Rhoa-Diaph1 Signaling Pathway Controls Localization Of The Phosphorylated Form To The Cell Membrane
Alternative Antibody Names Anti-Adenomatous Polyposis Coli Protein antibody
Anti-Protein Apc antibody
Anti-Deleted In Polyposis 2.5 antibody
Anti-APC antibody
Anti-DP2.5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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