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  • 产品名称：Anti-APH1B antibody (235-257) {FITC} (STJ500107)

  • 产品型号：STJ500107-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-APH1B antibody (235-257) {FITC} (STJ500107)
详情介绍：
Host: Rabbit
Applications: ELISA/WB
Reactivity: C.elegans/Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-APH1B (235-257) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.6 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: APH1B
Gene ID: 83464
Uniprot ID: APH1B_HUMAN
Immunogen Region: 235-257
Specificity: Does not cross react to other components of gamma secretase complex nor with other proteins.
Immunogen: Synthetic peptide taken within amino acid region 235-257 of Human Presenilin stabilizing protein.
Tissue Specificity Weakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart and brain.
Function Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
Protein Name Gamma-Secretase Subunit Aph-1b
Aph-1b
Aph-1beta
Presenilin-Stabilization Factor-Like
Database Links Reactome: R-HSA-1251985
Reactome: R-HSA-193692
Reactome: R-HSA-205043
Reactome: R-HSA-2122948
Reactome: R-HSA-2644606
Reactome: R-HSA-2894862
Reactome: R-HSA-2979096
Reactome: R-HSA-3928665
Reactome: R-HSA-9013507
Reactome: R-HSA-9013700
Reactome: R-HSA-9017802
Reactome: R-HSA-977225
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Gamma-Secretase Subunit Aph-1b antibody
Anti-Aph-1b antibody
Anti-Aph-1beta antibody
Anti-Presenilin-Stabilization Factor-Like antibody
Anti-APH1B antibody
Anti-PSFL antibody
Anti-UNQ688 antibody
Anti-PRO1328 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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