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  • 产品名称：Human TNFRSF21/DR6 protein (Recombinant) (C-hFc&His) (STJP001345)

  • 产品型号：STJP001345
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human TNFRSF21/DR6 protein (Recombinant) (C-hFc&His) (STJP001345)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human TNFRSF21/DR6-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human APP at 10 Mu g/mL (100 Mu L/well) can bind Mouse DR6 with a linear range of 0.002-1.8 Mu g/mL.
Gene Symbol: TNFRSF21
Gene ID: 27242
Uniprot ID: TNR21_HUMAN
Immunogen: Active Recombinant Human TNFRSF21/DR6 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln42-Leu350) of human TNFRSF21/DR6 (Accession #NP_055267.1) fused with a Fc, 6×His tag at the C-terminus.
Post Translational Modifications Oxidized in response to reactive oxygen species (ROS), leading to endocytosis.
Function Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21.this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. Also acts as a regulator of pyroptosis: recruits CASP8 in response to reactive oxygen species (ROS) and subsequent oxidation, leading to activation of GSDMC.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 21
Death Receptor 6
Cd Antigen Cd358
Database Links Reactome: R-HSA-1989781
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Endocytosed Following Oxidation In Response To Reactive Oxygen Species (Ros)
Alternative Protein Names Tumor Necrosis Factor Receptor Superfamily Member 21 protein
Death Receptor 6 protein
Cd Antigen Cd358 protein
TNFRSF21 protein
DR6 protein
UNQ437 protein
PRO868 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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