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  • 产品名称：PDE4D4 Blocking Peptide peptide (STJ504648)

  • 产品型号：STJ504648-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
PDE4D4 Blocking Peptide peptide (STJ504648)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: PDE4D4 Blocking Peptide is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PDE4D
Gene ID: 5144
Uniprot ID: PDE4D_HUMAN
Immunogen: Synthetic peptide corresponding to unique amino acid sequence on PDE4D4 variant gene.
Tissue Specificity Expressed in colonic epithelial cells (at protein level). Widespread.most abundant in skeletal muscle. Isoform 6: Detected in brain. Isoform 8: Detected in brain, placenta, lung and kidney. Isoform 7: Detected in heart and skeletal muscle.
Post Translational Modifications Long isoforms that share a conserved PKA phosphorylation site in the N-terminus are activated by PKA through phosphorylation. Isoform 3 and isoform 7 are activated by phosphorylation (in vitro), but not isoform 6. Isoform N3 and isoform 12 are phosphorylated on Ser-49, Ser-51, Ser-55 and Ser-59. Sumoylation of long isoforms by PIAS4 augments their activation by PKA phosphorylation and represses their inhibition by ERK phosphorylation.
Function Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Peptide Name Camp-Specific 3' -5'-Cyclic Phosphodiesterase 4d
Dpde3
Pde43
Database Links Reactome: R-HSA-180024
Reactome: R-HSA-418555
Cellular Localisation Apical Cell Membrane
Cytoplasm
Membrane
Cytoskeleton
Microtubule Organizing Center
Centrosome
Found In The Soluble Fraction
Associated With Membranes
And Associated With The Cytoskeleton And The Centrosome
Colocalized With Shank2 To The Apical Membrane Of Colonic Crypt Cells
Alternative Peptide Names Camp-Specific 3' -5'-Cyclic Phosphodiesterase 4d protein
Dpde3 protein
Pde43 protein
PDE4D protein
DPDE3 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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