产品详情
查看大图

  • 产品名称：Anti-AKR1C3 antibody (C-Term) (STJ70651)

  • 产品型号：STJ70651-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Anti-AKR1C3 antibody (C-Term) (STJ70651)
详情介绍：
Host: Goat
Applications: Pep-ELISA/WB/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-AKR1C3 (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.01-0.1µg/ml
IHC-5µg/ml
ELISA-antibody detection limit dilution 1:32000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: AKR1C3
Gene ID: 8644
Uniprot ID: AK1C3_HUMAN
Immunogen Region: C-Term
Accession Number: NP_003730.4
Immunogen Sequence: CFASHPNYPYSDEY
Function Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Acts as a NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain and regulates the metabolism of androgens, estrogens and progesterone. Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH. Acts preferentially as a 17-ketosteroid reductase and has the highest catalytic efficiency of the AKR1C enzyme for the reduction of delta4-androstenedione to form testosterone. Reduces prostaglandin (PG) D2 to 11beta-prostaglandin F2, progesterone to 20alpha-hydroxyprogesterone and estrone to 17beta-estradiol. Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also displays retinaldehyde reductase activity toward 9-cis-retinal.
Protein Name Aldo-Keto Reductase Family 1 Member C3
17-Beta-Hydroxysteroid Dehydrogenase Type 5
17-Beta-Hsd 5
3-Alpha-Hsd Type Ii - Brain
3-Alpha-Hydroxysteroid Dehydrogenase Type 2
3-Alpha-Hsd Type 2
Chlordecone Reductase Homolog Hakrb
Dihydrodiol Dehydrogenase 3
Dd-3
Dd3
Dihydrodiol Dehydrogenase Type I
Ha1753
Prostaglandin F Synthase
Pgfs
Testosterone 17-Beta-Dehydrogenase 5
Database Links Reactome: R-HSA-193368
Reactome: R-HSA-193775
Reactome: R-HSA-193807
Reactome: R-HSA-2162123
Reactome: R-HSA-5365859
Reactome: R-HSA-975634
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Aldo-Keto Reductase Family 1 Member C3 antibody
Anti-17-Beta-Hydroxysteroid Dehydrogenase Type 5 antibody
Anti-17-Beta-Hsd 5 antibody
Anti-3-Alpha-Hsd Type Ii - Brain antibody
Anti-3-Alpha-Hydroxysteroid Dehydrogenase Type 2 antibody
Anti-3-Alpha-Hsd Type 2 antibody
Anti-Chlordecone Reductase Homolog Hakrb antibody
Anti-Dihydrodiol Dehydrogenase 3 antibody
Anti-Dd-3 antibody
Anti-Dd3 antibody
Anti-Dihydrodiol Dehydrogenase Type I antibody
Anti-Ha1753 antibody
Anti-Prostaglandin F Synthase antibody
Anti-Pgfs antibody
Anti-Testosterone 17-Beta-Dehydrogenase 5 antibody
Anti-AKR1C3 antibody
Anti-DDH1 antibody
Anti-HSD17B5 antibody
Anti-KIAA0119 antibody
Anti-PGFS antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号