产品详情
查看大图

  • 产品名称：Human TYRO3 protein (Recombinant) (C-hFc&His) (STJP000976)

  • 产品型号：STJP000976
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Human TYRO3 protein (Recombinant) (C-hFc&His) (STJP000976)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human TYRO3-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human Gas6 at 2 Mu g/mL (100 Mu L/well) can bind Human TYRO3 with a linear range of 0.1-5.6 ng/mL.
Gene Symbol: TYRO3
Gene ID: 7301
Uniprot ID: TYRO3_HUMAN
Immunogen Region: Ala41-Ser428
Immunogen: Recombinant Human TYRO3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala41-Ser428) of human Tyro3/Dtk (Accession #NP_006284.2) fused with an Fc, 6×His tag at the C-terminus.
Tissue Specificity Abundant in the brain and lower levels in other tissues.
Post Translational Modifications Autophosphorylated.
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope.
Protein Name Tyrosine-Protein Kinase Receptor Tyro3
Tyrosine-Protein Kinase Byk
Tyrosine-Protein Kinase Dtk
Tyrosine-Protein Kinase Rse
Tyrosine-Protein Kinase Sky
Tyrosine-Protein Kinase Tif
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Tyrosine-Protein Kinase Receptor Tyro3 protein
Tyrosine-Protein Kinase Byk protein
Tyrosine-Protein Kinase Dtk protein
Tyrosine-Protein Kinase Rse protein
Tyrosine-Protein Kinase Sky protein
Tyrosine-Protein Kinase Tif protein
TYRO3 protein
BYK protein
DTK protein
RSE protein
SKY protein
TIF protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号