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  • 产品名称：Human Ubiquitin carboxyl-terminal hydrolase 16 protein (Recombinant) (His Tag) (STJP002530)

  • 产品型号：STJP002530-25
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human Ubiquitin carboxyl-terminal hydrolase 16 protein (Recombinant) (His Tag) (STJP002530)
详情介绍：
Host: sf9 Insect cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Ubiquitin carboxyl-terminal hydrolase 16-His Tag protein was developed from sf9 insect cells and has a target region of His Tag. For use in research applications.
Formulation: 20 mM Tris, 150 mM NaCl, 2 mM BetaME, 10% Glycerol
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: USP16
Gene ID: 10600
Uniprot ID: UBP16_HUMAN
Post Translational Modifications Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.
Function Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit.
Protein Name Ubiquitin Carboxyl-Terminal Hydrolase 16
Deubiquitinating Enzyme 16
Ubiquitin Thioesterase 16
Ubiquitin-Processing Protease Ubp-M
Ubiquitin-Specific-Processing Protease 16
Database Links Reactome: R-HSA-5689880
Cellular Localisation Nucleus
Cytoplasm
Alternative Protein Names Ubiquitin Carboxyl-Terminal Hydrolase 16 protein
Deubiquitinating Enzyme 16 protein
Ubiquitin Thioesterase 16 protein
Ubiquitin-Processing Protease Ubp-M protein
Ubiquitin-Specific-Processing Protease 16 protein
USP16 protein
MSTP039 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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