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  • 产品名称：Human Ubiquitin-activating enzyme E1/UBE1/UBA1 protein (Recombinant) (GST Tag) (STJP002520)

  • 产品型号：STJP002520-25
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human Ubiquitin-activating enzyme E1/UBE1/UBA1 protein (Recombinant) (GST Tag) (STJP002520)
详情介绍：
Host: sf9 Insect cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Ubiquitin-activating enzyme E1/UBE1/UBA1-GST Tag protein was developed from sf9 insect cells and has a target region of GST Tag. For use in research applications.
Formulation: 20 mM Tris, 150 mM NaCl, 2 mM BetaME, 10% Glycerol
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: UBA1
Gene ID: 7317
Uniprot ID: UBA1_HUMAN
Post Translational Modifications ISGylated.
Function Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites.
Protein Name Ubiquitin-Like Modifier-Activating Enzyme 1
Protein A1s9
Ubiquitin-Activating Enzyme E1
Database Links Reactome: R-HSA-8866652
Reactome: R-HSA-983168
Cellular Localisation Cytoplasm
Mitochondrion
Nucleus
Isoform 1: Nucleus
Isoform 2: Cytoplasm
Alternative Protein Names Ubiquitin-Like Modifier-Activating Enzyme 1 protein
Protein A1s9 protein
Ubiquitin-Activating Enzyme E1 protein
UBA1 protein
A1S9T protein
UBE1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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