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  • 产品名称：Human VEGF-A/VEGF121 (K321N) protein (Recombinant) (No tag) (STJP000791)

  • 产品型号：STJP000791
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human VEGF-A/VEGF121 (K321N) protein (Recombinant) (No tag) (STJP000791)
详情介绍：
Host: E. coli
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human VEGF-A/VEGF121 (K321N)-No tag protein was developed from e. coli and has a target region of No tag. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of 20mM TRIS, 100mM NaCl, pH 8.0. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human VEGF121 at 2 Mu g/mL (100 Mu L/well) can bind Human KDR with a linear range of 0.2-10 ng/mL.2. Measured in a cell proliferation assay using human umbilical vein endothelial cell
Gene Symbol: VEGFA
Gene ID: 7422
Uniprot ID: VEGFA_HUMAN
Immunogen: Recombinant Human VEGF-A/VEGF121 (K321N) Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ala207-Arg327 (Lys321Asn) ) of human VEGF121 (Accession #NP_001020541.2).
Tissue Specificity Higher expression in pituitary tumors than the pituitary gland. Isoform VEGF189: Widely expressed. Isoform VEGF165: Widely expressed. Isoform VEGF121: Widely expressed. Isoform VEGF206: Not widely expressed. Isoform VEGF145: Not widely expressed.
Post Translational Modifications Vascular endothelial growth factor A, long form: Produced by use of an alternative upstream CUG codon and post-translationally processed into the N-terminal N-VEGF form and the C-terminal secreted VEGFA form.
Function N-VEGF: Participates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A. Involved in protecting cells from hypoxia-mediated cell death. VEGFA: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Binds to the NRP1/neuropilin-1 receptor. Binding to NRP1 initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Also binds the DEAR/FBXW7-AS1 receptor. Isoform VEGF165B: Binds to the KDR receptor but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
Protein Name Vascular Endothelial Growth Factor A - Long Form
L-Vegf
Vascular Permeability Factor
Vpf Cleaved Into - N-Vegf - Vegfa
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-1234158
Reactome: R-HSA-194138
Reactome: R-HSA-194313
Reactome: R-HSA-195399
Reactome: R-HSA-4420097 P15692-4
Reactome: R-HSA-5218921 P15692-4
Reactome: R-HSA-6785807
Reactome: R-HSA-8866910
Reactome: R-HSA-9679191 P15692-4
Cellular Localisation N-Vegf: Cytoplasm
Nucleus
Cytoplasmic In Normoxic Conditions And Localizes To The Nucleus Under Hypoxic Conditions
Vegfa: Secreted
Isoform L-Vegf189: Endoplasmic Reticulum
Golgi Apparatus
Secreted
Extracellular Space
Extracellular Matrix
Isoform Vegf121: Secreted
Isoform Vegf165: Secreted
Isoform Vegf189: Secreted
Cell-Associated After Secretion And Is Bound Avidly By Heparin And The Extracellular Matrix
Although It May Be Released As A Soluble Form By Heparin
Heparinase Or Plasmin
Alternative Protein Names Vascular Endothelial Growth Factor A - Long Form protein
L-Vegf protein
Vascular Permeability Factor protein
Vpf Cleaved Into - N-Vegf - Vegfa protein
VEGFA protein
VEGF protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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