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  • 产品名称：Anti-ACPP/PAP, Biotinylated antibody (269-282) {Biotin} (STJ73506)

  • 产品型号：STJ73506-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ACPP/PAP, Biotinylated antibody (269-282) {Biotin} (STJ73506)
详情介绍：
Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-ACPP/PAP, Biotinylated (269-282) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.01-0.03µg/ml
ELISA-antibody detection limit dilution 1:32000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: ACP3
Gene ID: 55
Uniprot ID: PPAP_HUMAN
Immunogen Region: 269-282
Accession Number: NP_001127666.1; NP_001090.2
Specificity: This antibody is expected to recognize both reported isoforms (NP_001127666.1; NP_001090.2).
Immunogen Sequence: NHMKRATQIPSYKK.
Post Translational Modifications N-glycosylated. High mannose content, partially sialylated and fucosylated biantennary complex. Also fucosylated with partially sialylated triantennary complex oligosaccharides. Proteolytically cleaved in seminal fluid to produce several peptides. Peptide PAPf39, the most prominent, forms amyloid beta-sheet fibrils, SEVI (semen-derived enhancer of viral infection).
Function A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma. Isoform 2: Tyrosine phosphatase that acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling. In addition to its tyrosine phosphatase activity has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. PAPf39: (Microbial infection) Forms amyloid beta-sheet fibrils in semen. These fibrils, termed SEVI (semen-derived enhancer of viral infection) capture HIV virions, attach them to target cells and enhance infection. SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea. Target cell attachment and enhancement of HIV infection is inhibited by surfen. Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection.
Protein Name Prostatic Acid Phosphatase
Pap
5'-Nucleotidase
5'-Nt
Acid Phosphatase 3
Ecto-5'-Nucleotidase
Protein Tyrosine Phosphatase Acp3
Thiamine Monophosphatase
Tmpase Cleaved Into - Papf39
Database Links Reactome: R-HSA-6798695
Cellular Localisation Isoform 1: Secreted
Isoform 2: Cell Membrane
Single-Pass Type I Membrane Protein
Lysosome Membrane
Nucleus
Cytoplasm
Cytosol
Appears To Shuttle Between The Cell Membrane And Intracellular Vesicles
Colocalizes With Flot1 At Cell Membrane And In Intracellular Vesicles
Colocalizes With Lamp2 On The Lysosome Membrane
Alternative Antibody Names Anti-Prostatic Acid Phosphatase antibody
Anti-Pap antibody
Anti-5'-Nucleotidase antibody
Anti-5'-Nt antibody
Anti-Acid Phosphatase 3 antibody
Anti-Ecto-5'-Nucleotidase antibody
Anti-Protein Tyrosine Phosphatase Acp3 antibody
Anti-Thiamine Monophosphatase antibody
Anti-Tmpase Cleaved Into - Papf39 antibody
Anti-ACP3 antibody
Anti-ACPP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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