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  • 产品名称：Anti-ADAMTS13 antibody (50-150) [S6MR] (STJ11103516)

  • 产品型号：STJ11103516
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ADAMTS13 antibody (50-150) [S6MR] (STJ11103516)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-ADAMTS13 (50-150) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Monoclonal
Clone ID: S6MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ADAMTS13
Gene ID: 11093
Uniprot ID: ATS13_HUMAN
Immunogen Region: 50-150
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human ADAMTS13 (Q76LX8).
Immunogen Sequence: LSPGAPLKGRPPSPGFQRQR QRQRRAAGGILHLELLVAVG PDVFQAHQEDTERYVLTNLN IGAELLRDPSLGAQFRVHLV KMVILTEPEGAPNITANLTS S
Tissue Specificity Plasma. Expressed primarily in liver.
Post Translational Modifications Glycosylated. O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS13. May also be C-glycosylated on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and also N-glycosylated. These other glycosylations can also facilitate secretion. The precursor is processed by a furin endopeptidase which cleaves off the pro-domain.
Function Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation.
Protein Name A Disintegrin And Metalloproteinase With Thrombospondin Motifs 13
Adam-Ts 13
Adam-Ts13
Adamts-13
Von Willebrand Factor-Cleaving Protease
Vwf-Cp
Vwf-Cleaving Protease
Database Links Reactome: R-HSA-5083635
Reactome: R-HSA-5173214
Cellular Localisation Secreted
Secretion Enhanced By O-Fucosylation Of Tsp Type-1 Repeats
Alternative Antibody Names Anti-A Disintegrin And Metalloproteinase With Thrombospondin Motifs 13 antibody
Anti-Adam-Ts 13 antibody
Anti-Adam-Ts13 antibody
Anti-Adamts-13 antibody
Anti-Von Willebrand Factor-Cleaving Protease antibody
Anti-Vwf-Cp antibody
Anti-Vwf-Cleaving Protease antibody
Anti-ADAMTS13 antibody
Anti-C9orf8 antibody
Anti-UNQ6102 antibody
Anti-PRO20085 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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