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  • 产品名称：Human IFN-gamma R1/CD119 protein (Recombinant) (C-His) (STJP002598)

  • 产品型号：STJP002598
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human IFN-gamma R1/CD119 protein (Recombinant) (C-His) (STJP002598)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human IFN-gamma R1/CD119-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human FNGR1/CD119 at 1 Mu g/mL (100 Mu L/well) can bind Human IFNG with a linear range of 0.98-1.97 ng/mL.
Gene Symbol: IFNGR1
Gene ID: 3459
Uniprot ID: INGR1_HUMAN
Immunogen Region: Met1-Gly245
Immunogen: Recombinant Human IFN-gamma R1/CD119 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Gly245) of human IFNGR1/CD119 (Accession #NP_000407.1) fused with a 6×His tag at the C-terminus.
Function Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription. STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1.
Protein Name Interferon Gamma Receptor 1
Ifn-Gamma Receptor 1
Ifn-Gamma-R1
Cdw119
Interferon Gamma Receptor Alpha-Chain
Ifn-Gamma-R-Alpha
Cd Antigen Cd119
Database Links Reactome: R-HSA-877300
Reactome: R-HSA-877312
Reactome: R-HSA-9679191
Reactome: R-HSA-9732724
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Interferon Gamma Receptor 1 protein
Ifn-Gamma Receptor 1 protein
Ifn-Gamma-R1 protein
Cdw119 protein
Interferon Gamma Receptor Alpha-Chain protein
Ifn-Gamma-R-Alpha protein
Cd Antigen Cd119 protein
IFNGR1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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