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  • 产品名称：Human IFNAR1 protein (Recombinant) (C-His & Avi) {Biotin} (STJP002275)

  • 产品型号：STJP002275-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human IFNAR1 protein (Recombinant) (C-His & Avi) {Biotin} (STJP002275)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human IFNAR1-C-His & Avi protein was developed from hek293 cells and has a target region of C-His & Avi. For use in research applications.
Conjugation: Biotin
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Endotoxin: Less than 1EU per Mu g by the LAL method.
Gene Symbol: IFNAR1
Gene ID: 3454
Uniprot ID: INAR1_HUMAN
Immunogen Region: Lys28-Lys436
Immunogen: Recombinant Biotinylated Human IFNAR1/IFN alpha/beta R1 Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal.；It contains Lys28-Lys436.
Post Translational Modifications Ubiquitinated, leading to its internalization and degradation. Polyubiquitinated via 'Lys-48'-linked and 'Lys-63'-linked ubiquitin chains, leading to receptor internalization and lysosomal degradation. The 'Lys-63'-linked ubiquitin chains are cleaved off by the BRISC complex. Phosphorylated on tyrosine residues in response to interferon-binding: phosphorylation by TYK2 tyrosine kinase creates docking sites for STAT proteins. Phosphorylated on serine residues in response to interferon binding.this promotes interaction with FBXW11 and ubiquitination. Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT2.
Function Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.
Protein Name Interferon Alpha/Beta Receptor 1
Ifn-R-1
Ifn-Alpha/Beta Receptor 1
Cytokine Receptor Class-Ii Member 1
Cytokine Receptor Family 2 Member 1
Crf2-1
Type I Interferon Receptor 1
Database Links Reactome: R-HSA-909733
Reactome: R-HSA-912694
Reactome: R-HSA-9679191
Reactome: R-HSA-9705671
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Late Endosome
Lysosome
Interferon Binding Triggers Internalization Of The Receptor From The Cell Membrane Into Endosomes And Then Into Lysosomes
Alternative Protein Names Interferon Alpha/Beta Receptor 1 protein
Ifn-R-1 protein
Ifn-Alpha/Beta Receptor 1 protein
Cytokine Receptor Class-Ii Member 1 protein
Cytokine Receptor Family 2 Member 1 protein
Crf2-1 protein
Type I Interferon Receptor 1 protein
IFNAR1 protein
IFNAR protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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