产品详情
查看大图

  • 产品名称：Human IL-36Ra/IL-1F5 protein (Recombinant) (C-His) (STJP000805)

  • 产品型号：STJP000805
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Human IL-36Ra/IL-1F5 protein (Recombinant) (C-His) (STJP000805)
详情介绍：
Host: E. coli
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human IL-36Ra/IL-1F5-C-His protein was developed from e. coli and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of 20mM TRIS, 150mM NaCl, pH 8.0. Contact us for customized product form or formulation.
Gene Symbol: IL36RN
Gene ID: 26525
Uniprot ID: I36RA_HUMAN
Immunogen: Recombinant Human IL-36Ra/IL-1F5 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Val2-Asp155) of human IL-36Ra (Accession #NP_036407.1) fused with a 6×His tag at the C-terminus.
Tissue Specificity Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.
Function Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response.similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.
Protein Name Interleukin-36 Receptor Antagonist Protein
Il-36ra
Fil1 Delta
Il-1-Related Protein 3
Il-1rp3
Interleukin-1 Hy1
Il-1hy1
Interleukin-1 Delta
Il-1 Delta
Interleukin-1 Family Member 5
Il-1f5
Interleukin-1 Receptor Antagonist Homolog 1
Il-1ra Homolog 1
Interleukin-1-Like Protein 1
Il-1l1
Database Links Reactome: R-HSA-9014826
Cellular Localisation Cytoplasm
Secreted
The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10
It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion
Alternative Protein Names Interleukin-36 Receptor Antagonist Protein protein
Il-36ra protein
Fil1 Delta protein
Il-1-Related Protein 3 protein
Il-1rp3 protein
Interleukin-1 Hy1 protein
Il-1hy1 protein
Interleukin-1 Delta protein
Il-1 Delta protein
Interleukin-1 Family Member 5 protein
Il-1f5 protein
Interleukin-1 Receptor Antagonist Homolog 1 protein
Il-1ra Homolog 1 protein
Interleukin-1-Like Protein 1 protein
Il-1l1 protein
IL36RN protein
FIL1D protein
IL1F5 protein
IL1HY1 protein
IL1L1 protein
IL1RP3 protein
UNQ1896 protein
PRO4342 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号