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  • 产品名称：Anti-AKR1B1 antibody (STJ98464)

  • 产品型号：STJ98464
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-AKR1B1 antibody (STJ98464)
详情介绍：
Host: Mouse
Applications: WB
Reactivity: Human/Mouse/Dog/Rabbit
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Aldo-keto reductase family 1 member B1 is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Conjugation: Unconjugated
Formulation: Liquid in 0.1M Tris-Glycine (pH7.4, 150 mM NaCl) , 0.2% Sodium Azide and 50% Glycerol.
Purification: Affinity purification
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: AKR1B1
Gene ID: 231
Uniprot ID: ALDR_HUMAN
Specificity: Aldose Reductase Monoclonal Antibody detects endogenous levels of Aldose Reductase protein.
Immunogen: Purified recombinant human Aldose Reductase protein fragments expressed in E.coli.
Function Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls).
Protein Name Aldo-Keto Reductase Family 1 Member B1
Aldehyde Reductase
Aldose Reductase
Ar
Database Links Reactome: R-HSA-196108
Reactome: R-HSA-5652227
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Aldo-Keto Reductase Family 1 Member B1 antibody
Anti-Aldehyde Reductase antibody
Anti-Aldose Reductase antibody
Anti-Ar antibody
Anti-AKR1B1 antibody
Anti-ALDR1 antibody
Anti-ALR2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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