产品详情
查看大图

  • 产品名称：Anti-AKR1C4 antibody (1-80 aa) (STJ190533)

  • 产品型号：STJ190533
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Anti-AKR1C4 antibody (1-80 aa) (STJ190533)
详情介绍：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Aldo-keto reductase family 1 member C4 (1-80 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: AKR1C4
Gene ID: 1109
Uniprot ID: AK1C4_HUMAN
Immunogen Region: 1-80 aa
Specificity: AK1C4 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from the human protein at the amino acid range 1-80
Post Translational Modifications The N-terminus is blocked.
Function Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Liver specific enzyme that acts as NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain. Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH. Acts preferentially as a 3-alpha-hydroxysteroid dehydrogenase (HSD) with a subsidiary 3-beta-HSD activity. Catalyzes efficiently the transformation of the potent androgen 5-alpha-dihydrotestosterone (5alpha-DHT or 17beta-hydroxy-5alpha-androstan-3-one) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Catalyzes the reduction of estrone into 17beta-estradiol but with low efficiency. Metabolizes a broad spectrum of natural and synthetic therapeutic steroid and plays an important role in metabolism of androgens, estrogens, progestereone and conjugated steroids. Catalyzes the biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leading to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
Protein Name Aldo-Keto Reductase Family 1 Member C4
3-Alpha-Hydroxysteroid Dehydrogenase Type I
3-Alpha-Hsd1
3alpha-Hydroxysteroid 3-Dehydrogenase
Chlordecone Reductase
Cdr
Dihydrodiol Dehydrogenase 4
Dd-4
Dd4
Hakra
Database Links Reactome: R-HSA-193368
Reactome: R-HSA-193775
Reactome: R-HSA-193807
Reactome: R-HSA-975634
Cellular Localisation Cytoplasm
Cytosol
Alternative Antibody Names Anti-Aldo-Keto Reductase Family 1 Member C4 antibody
Anti-3-Alpha-Hydroxysteroid Dehydrogenase Type I antibody
Anti-3-Alpha-Hsd1 antibody
Anti-3alpha-Hydroxysteroid 3-Dehydrogenase antibody
Anti-Chlordecone Reductase antibody
Anti-Cdr antibody
Anti-Dihydrodiol Dehydrogenase 4 antibody
Anti-Dd-4 antibody
Anti-Dd4 antibody
Anti-Hakra antibody
Anti-AKR1C4 antibody
Anti-CHDR antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号