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  • 产品名称：LAT Blocking Peptide for STJ501581 peptide (STJ504292)

  • 产品型号：STJ504292-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
LAT Blocking Peptide for STJ501581 peptide (STJ504292)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: LAT Blocking Peptide for STJ501581 is synthetically produced from the 40-90 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: LAT
Gene ID: 27040
Uniprot ID: LAT_HUMAN
Immunogen Region: 40-90
Specificity: This blocking peptide is recommended for use in combination with LAT antibody, STJ501581
Immunogen: Synthetic peptide taken within amino acid region 40-90 on LAT protein.
Tissue Specificity Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).
Post Translational Modifications Phosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation.which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ. Phosphorylated by ITK leading to the recruitment of VAV1 to LAT-containing complexes. Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation. 'Lys-63'-linked ubiquitinated by TRAF6.
Function Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
Peptide Name Linker For Activation Of T-Cells Family Member 1
36 Kda Phosphotyrosine Adapter Protein
Pp36
P36-38
Database Links Reactome: R-HSA-114604
Reactome: R-HSA-202433
Reactome: R-HSA-2424491 O43561-2
Reactome: R-HSA-2454202 O43561-2
Reactome: R-HSA-2871796 O43561-2
Reactome: R-HSA-2871809 O43561-2
Reactome: R-HSA-5673001 O43561-2
Cellular Localisation Cell Membrane
Single-Pass Type Iii Membrane Protein
Present In Lipid Rafts
Alternative Peptide Names Linker For Activation Of T-Cells Family Member 1 protein
36 Kda Phosphotyrosine Adapter Protein protein
Pp36 protein
P36-38 protein
LAT protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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