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  • 产品名称：Human NKG2C/CD159c protein (Recombinant) (N-His-Avi) {Biotin} (STJP001693)

  • 产品型号：STJP001693
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human NKG2C/CD159c protein (Recombinant) (N-His-Avi) {Biotin} (STJP001693)
详情介绍：
Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human NKG2C/CD159c-N-His-Avi protein was developed from hek293 and has a target region of N-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: KLRC2
Gene ID: 3822
Uniprot ID: NKG2C_HUMAN
Immunogen Region: Glu98-Leu231
Immunogen: DNA sequence encoding Human NKG2C/CD159c including a N-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Function Immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy. Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection. Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation.
Protein Name Nkg2-C Type Ii Integral Membrane Protein
Cd159 Antigen-Like Family Member C
Nk Cell Receptor C
Nkg2-C-Activating Nk Receptor
Cd Antigen Cd159c
Database Links Reactome: R-HSA-2172127
Reactome: R-HSA-2424491
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Alternative Protein Names Nkg2-C Type Ii Integral Membrane Protein protein
Cd159 Antigen-Like Family Member C protein
Nk Cell Receptor C protein
Nkg2-C-Activating Nk Receptor protein
Cd Antigen Cd159c protein
KLRC2 protein
NKG2C protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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