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  • 产品名称：Human ARG2 (Arginase-2, mitochondrial) Sandwich ELISA (STJE0004107)

  • 产品型号：STJE0004107
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human ARG2 (Arginase-2, mitochondrial) Sandwich ELISA (STJE0004107)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Sensitivity: 18.75pg/mL
Detection Limit: 31.25~2000pg/mL
Short Description: This ARG2 Sandwich ELISA is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: If unopened the kit may be stored at 2-8°C for up to 1 month. If the kit will not be used within 1 month, store the components separately, according to the component table in the manual.
Assay Time: 3.5h
Detection: Colormetric
Gene Symbol: ARG2
Gene ID: 384
Uniprot ID: ARGI2_HUMAN
Specificity: This kit recognizes Human ARG2 in samples. No significant cross-reactivity or interference between Human ARG2 and analogues was observed.
Sample Type: Serum, plasma and other biological fluids
Function May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism. In fetal dendritic cells may play a role in promoting immune suppression and T cell TNF-alpha production during gestation. Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction. Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling. Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity. Since NOS is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase-2 plays a role in both male and female sexual arousal.
Protein Name Arginase-2 - Mitochondrial
Arginase Ii
Kidney-Type Arginase
Non-Hepatic Arginase
Type Ii Arginase
Database Links Reactome: R-HSA-70635
Cellular Localisation Mitochondrion
Alternative ELISA Names Arginase-2 - Mitochondrial ELISA kit
Arginase Ii ELISA kit
Kidney-Type Arginase ELISA kit
Non-Hepatic Arginase ELISA kit
Type Ii Arginase ELISA kit
ARG2 ELISA kit
Specificity This kit recognizes Human ARG2 in samples. No significant cross-reactivity or interference between Human ARG2 and analogues was observed.
Reproducibility Both intra-CV and inter-CV are

Information sourced from Uniprot.org


Item Specifications Storage
Micro ELISA Plate (Dismountable) 96T: 8 wells ×12 strips strips -20℃, 6 months
Reference Standard 96T: 2 vials 48T: 1 vial -20℃, 6 months
Concentrated Biotinylated Detection Ab (100×) 96T: 1 vial, 120 μL 60 μL -20℃, 6 months
Concentrated HRP Conjugate (100×) 96T: 1 vial, 120 μL 60 μL -20℃ (Protect from light), 6 months
Reference Standard & Sample Diluent 1 vial, 20 mL 2-8°C, 6 months
Biotinylated Detection Ab Diluent 1 vial, 14 mL 2-8°C, 6 months
HRP Conjugate Diluent 1 vial, 14 mL 2-8°C, 6 months
Concentrated Wash Buffer (25×) 1 vial, 30 mL 2-8°C, 6 months
Substrate Reagent 1 vial, 10 mL 2-8℃ (Protect from light)
Stop Solution 1 vial, 10 mL 2-8°C
Plate Sealer 5 pieces
Manual 1 copy
Certificate of Analysis 1 copy

Sample Type Range (%) Average Recovery (%)
Serum(n=8) 86-94 90
EDTA plasma (n=8) 84-94 91
Cell culture media (n=8) 97-106 100

Intra-assay Precision Intra-assay Precision Intra-assay Precision Inter-assay Precision Inter-assay Precision Inter-assay Precision
Sample 1.00 2.00 3.00 1.00 2.00 3.00
n 20.00 20.00 20.00 20.00 20.00 20.00
Mean (pg/mL) 95.15 249.44 828.33 87.41 211.48 934.70
Standard deviation 5.40 11.90 38.93 4.39 10.55 49.07
CV (%) 5.68 4.77 4.70 5.02 4.99 5.25
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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