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  • 产品名称：Human PDGFR-alpha/CD140a protein (Recombinant) (C-hFc & His) (STJP002569)

  • 产品型号：STJP002569
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human PDGFR-alpha/CD140a protein (Recombinant) (C-hFc & His) (STJP002569)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human PDGFR-alpha/CD140a-C-hFc & His protein was developed from hek293 cells and has a target region of C-hFc & His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized recombinant Human PDGF-B at 2 Mu g/mL (100 Mu L/well) can bind recombinant Human PDGFRA, the EC50 of Human PDGFRA is 109 ng/mL.
Gene Symbol: PDGFRA
Gene ID: 5156
Uniprot ID: PGFRA_HUMAN
Immunogen Region: Gln24-Glu524
Immunogen: Recombinant Human PDGFR-alpha/CD140a Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln24-Glu524) of human PDGFRa/CD140a (Accession #NP_006197.1) fused with an Fc, 6×His tag at the C-terminus.
Post Translational Modifications N-glycosylated. Ubiquitinated, leading to its internalization and degradation. Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-731 and Tyr-742 is important for interaction with PIK3R1. Phosphorylation at Tyr-720 and Tyr-754 is important for interaction with PTPN11. Phosphorylation at Tyr-762 is important for interaction with CRK. Phosphorylation at Tyr-572 and Tyr-574 is important for interaction with SRC and SRC family members. Phosphorylation at Tyr-988 and Tyr-1018 is important for interaction with PLCG1.
Function Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades.the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.
Protein Name Platelet-Derived Growth Factor Receptor Alpha
Pdgf-R-Alpha
Pdgfr-Alpha
Alpha Platelet-Derived Growth Factor Receptor
Alpha-Type Platelet-Derived Growth Factor Receptor
Cd140 Antigen-Like Family Member A
Cd140a Antigen
Platelet-Derived Growth Factor Alpha Receptor
Platelet-Derived Growth Factor Receptor 2
Pdgfr-2
Cd Antigen Cd140a
Database Links Reactome: R-HSA-1257604
Reactome: R-HSA-186763
Reactome: R-HSA-186797
Reactome: R-HSA-2219530
Reactome: R-HSA-5673001
Reactome: R-HSA-6811558
Reactome: R-HSA-9673767
Reactome: R-HSA-9673770
Reactome: R-HSA-9674396
Reactome: R-HSA-9674401
Reactome: R-HSA-9674403
Reactome: R-HSA-9674404
Reactome: R-HSA-9674428
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Projection
Cilium
Golgi Apparatus
Alternative Protein Names Platelet-Derived Growth Factor Receptor Alpha protein
Pdgf-R-Alpha protein
Pdgfr-Alpha protein
Alpha Platelet-Derived Growth Factor Receptor protein
Alpha-Type Platelet-Derived Growth Factor Receptor protein
Cd140 Antigen-Like Family Member A protein
Cd140a Antigen protein
Platelet-Derived Growth Factor Alpha Receptor protein
Platelet-Derived Growth Factor Receptor 2 protein
Pdgfr-2 protein
Cd Antigen Cd140a protein
PDGFRA protein
PDGFR2 protein
RHEPDGFRA protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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