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  • 产品名称：Niemann Pick C1 Blocking Peptide peptide (STJ504424)

  • 产品型号：STJ504424-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Niemann Pick C1 Blocking Peptide peptide (STJ504424)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Niemann Pick C1 Blocking Peptide is synthetically produced from the 1228-1278 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Dilution Range: WB:
IHC: 1:100
ICC: 1:100
IF: 1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: NPC1
Gene ID: 4864
Uniprot ID: NPC1_HUMAN
Immunogen Region: 1228-1278
Immunogen: Synthetic peptide taken within amino acid region 1228-1278 on human Niemann-Pick C1 protein.
Post Translational Modifications N-glycosylated.
Function Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). Inhibits cholesterol-mediated mTORC1 activation throught its interaction with SLC38A9. (Microbial infection) Acts as an endosomal entry receptor for ebolavirus.
Peptide Name Npc Intracellular Cholesterol Transporter 1
Niemann-Pick C1 Protein
Database Links Reactome: R-HSA-8964038
Cellular Localisation Late Endosome Membrane
Multi-Pass Membrane Protein
Lysosome Membrane
Alternative Peptide Names Npc Intracellular Cholesterol Transporter 1 protein
Niemann-Pick C1 Protein protein
NPC1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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