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  • 产品名称：Human Semaphorin-4D/SEMA4D/CD100 protein (Recombinant) (C-His) (STJP001081)

  • 产品型号：STJP001081
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human Semaphorin-4D/SEMA4D/CD100 protein (Recombinant) (C-His) (STJP001081)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Semaphorin-4D/SEMA4D/CD100-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human SEMA4D Protein at 1 Mu g/mL (100 Mu L/well) can bind CD100 Rabbit mAb with a linear range of 0.012-0.88 ng/mL.
Gene Symbol: SEMA4D
Gene ID: 10507
Uniprot ID: SEM4D_HUMAN
Immunogen: Recombinant Human Semaphorin-4D/SEMA4D/CD100 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Met22-Arg734) of human Semaphorin 4D (Accession #NP_006369.3) fused with a 6×His tag at the C-terminus.
Tissue Specificity Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver.
Function Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling. Regulates GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner. Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA. Promotes the migration of cerebellar granule cells. Plays a role in the immune system.induces B-cells to aggregate and improves their viability (in vitro). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway.
Protein Name Semaphorin-4d
A8
Bb18
Gr3
Cd Antigen Cd100
Database Links Reactome: R-HSA-416550
Reactome: R-HSA-416572
Reactome: R-HSA-416700
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Semaphorin-4d protein
A8 protein
Bb18 protein
Gr3 protein
Cd Antigen Cd100 protein
SEMA4D protein
C9orf164 protein
CD100 protein
SEMAJ protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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