产品详情
简单介绍:
Phospholipase A2 Positive Control peptide (Phospho) (STJ504743)
详情介绍:
Applications: | WB |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Phospho-Phospholipase A2 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications. |
Dilution Range: | WB: 1:500 |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Gene Symbol: | PLAA |
Gene ID: | 9373 |
Uniprot ID: | PLAP_HUMAN |
Function | Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis. |
Peptide Name | Phospholipase A-2-Activating Protein Pla2p Plap |
Cellular Localisation | Nucleus Cytoplasm Synapse Recruited To Damaged Lysosomes Decorated With K48-Linked Ubiquitin Chains |
Alternative Peptide Names | Phospholipase A-2-Activating Protein protein Pla2p protein Plap protein PLAA protein PLAP protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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