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  • 产品名称：Human/Mouse/Rat TGF-beta 3 protein (Recombinant) (No tag) (STJP002647)

  • 产品型号：STJP002647
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human/Mouse/Rat TGF-beta 3 protein (Recombinant) (No tag) (STJP002647)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human/Mouse/Rat TGF-beta 3-No tag protein was developed from hek293 cells and has a target region of No tag. For use in research applications.
Formulation: Lyophilized from a 0.2 Mu m filtered solution of 50mM Glycine-HCl, 150mM NaCl, pH 2.5.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TGFB3
Gene ID: 7043
Uniprot ID: TGFB3_HUMAN
Immunogen Region: Tyr340Phe
Immunogen: Recombinant Human/Mouse/Rat TGF-beta 3 Protein is produced by Human cells expression system. The target protein is expressed with sequence (Ala301-Ser412 (Tyr340Phe) ) of human TGF-beta 3/TGFB3 (Accession #P10600).
Function Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Latency-associated peptide: Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3. Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus. TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3. Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal.
Protein Name Transforming Growth Factor Beta-3 Proprotein Cleaved Into - Latency-Associated Peptide
Lap - Transforming Growth Factor Beta-3
Tgf-Beta-3
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-2129379
Reactome: R-HSA-2173789
Reactome: R-HSA-3000178
Cellular Localisation Latency-Associated Peptide: Secreted
Extracellular Space
Extracellular Matrix
Transforming Growth Factor Beta-3: Secreted
Alternative Protein Names Transforming Growth Factor Beta-3 Proprotein Cleaved Into - Latency-Associated Peptide protein
Lap - Transforming Growth Factor Beta-3 protein
Tgf-Beta-3 protein
TGFB3 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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