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  • 产品名称：Human CCR5 (Chemokine C-C-Motif Receptor 5) Sandwich ELISA Kit (STJE0007776)

  • 产品型号：STJE0007776
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human CCR5 (Chemokine C-C-Motif Receptor 5) Sandwich ELISA Kit (STJE0007776)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 6.5pg/mL
Detection Limit: 15.6-1000pg/mL
Short Description: This CCR5 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: CCR5
Gene ID: 1234
Uniprot ID: CCR5_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung.
Post Translational Modifications Sulfated on at least 2 of the N-terminal tyrosines. Sulfation contributes to the efficiency of HIV-1 entry and is required for efficient binding of the chemokines, CCL3 and CCL4. O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site even if Ser-7 may be also O-glycosylated. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen. Palmitoylation in the C-terminal is important for cell surface expression, and to a lesser extent, for HIV entry. Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.
Function Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor. (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1.
Protein Name C-C Chemokine Receptor Type 5
C-C Ckr-5
Cc-Ckr-5
Ccr-5
Ccr5
Chemr13
Hiv-1 Fusion Coreceptor
Cd Antigen Cd195
Database Links Reactome: R-HSA-173107
Reactome: R-HSA-380108
Reactome: R-HSA-418594
Reactome: R-HSA-6783783
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative ELISA Names C-C Chemokine Receptor Type 5 ELISA kit
C-C Ckr-5 ELISA kit
Cc-Ckr-5 ELISA kit
Ccr-5 ELISA kit
Ccr5 ELISA kit
Chemr13 ELISA kit
Hiv-1 Fusion Coreceptor ELISA kit
Cd Antigen Cd195 ELISA kit
CCR5 ELISA kit
CMKBR5 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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